Application of a high-throughput quantitative PCR system for simultaneous monitoring of SARS-CoV-2 variants and other pathogenic viruses in wastewaterArticle Published on 2022-12-202022-11-15 Journal: The Science of the total environment [Category] COVID19(2023년), SARS, 변종, 치료기술, 치료제, [키워드] acute respiratory syndrome Alpha variant analyzed application applied assays can be used collected Community coronavirus coronavirus disease COVID-19 delta variant demonstrated detect eight epidemiologically FIVE Health High-throughput qPCR highlighting increase Japan L452R labor-intensive likelihood Mie N501Y nine nucleotide nucleotide substitution pathogenic virus pathogenic viruses Pathogenic viruses, SARS-CoV-2 Patient PCR positive prevalent qPCR quantitative PCR quarantine reported RNA RT-qPCR SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 variant separated Surveillance target tested time-consuming Treatment virus viruses Volume wastewater Wastewater. Yokkaichi [DOI] 10.1016/j.scitotenv.2022.158659 PMC 바로가기
Comparative global B cell receptor repertoire difference induced by SARS-CoV-2 infection or vaccination via single-cell V(D)J sequencingSARS-CoV-2 감염 또는 단일 세포 V(D)J 시퀀싱을 통한 백신 접종에 의해 유도된 비교 글로벌 B 세포 수용체 레퍼토리 차이Article Published on 2022-12-012022-09-12 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 진단, [키워드] antibody B cell BBIBP-CorV BCR BCR repertoire change Comparative COVID-19 COVID-19 recovered patient dynamic FIVE group groups Guidance healthy healthy donor humoral immune response IGHV3-23 IGHV3-33 inactivated Inactivated vaccine Infection performed Precision proportion receptor SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein SARS-CoV-2 vaccination SARS-CoV-2 vaccine Sequencing single-cell Single-cell RNA sequencing single-cell RNA sequencing. subject subjects the SARS-CoV-2 treated vaccination Vaccine [DOI] 10.1080/22221751.2022.2105261 PMC 바로가기 [Article Type] Article
SARS-CoV-2 fusion-inhibitory lipopeptides maintain high potency against divergent variants of concern including OmicronSARS-CoV-2 융합 억제 리포펩티드는 오미크론을 포함한 다양한 관심 변종에 대해 높은 효능을 유지합니다Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] activity Alpha antiviral activity Beta broad-spectrum antiviral broad-spectrum antivirals Cell Cell fusion cell-cell fusion combating COVID-19 pandemic D614G Delta drugs effective vaccine Effective vaccines exhibited FIVE fusion inhibitor Gamma Impact Infection inhibiting inhibitor inhibitors Lambda lipopeptide maintain mutant omicron Omicron variant other variant other variants outbreak pseudovirus pseudovirus pseudovirus infection pseudoviruses reduced S protein S proteins SARS-CoV-2 significantly the S protein therapeutic variant variants variants of concern variants of concern. VoC VOCs wild-type WT virus [DOI] 10.1080/22221751.2022.2098060 PMC 바로가기 [Article Type] Article
A nasal omicron vaccine booster elicits potent neutralizing antibody response against emerging SARS-CoV-2 variants비강 오미크론 백신 부스터는 새로운 SARS-CoV-2 변이체에 대한 강력한 중화 항체 반응을 이끌어냅니다.Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] absence adjuvants administration antibody Antibody Response boost booster Bronchoalveolar lavage caused clinical trial composed COVID-19 COVID-19 pandemic current deaths delta variant described disease severity domain dose effective Elevation elicit evidenced FIVE fused human infection human infections humans IgA Immunity immunogen intranasal leads mice MOST mucosal nasal nasal protein vaccine booster Neutralizing activity neutralizing antibody Neutralizing antibody response omicron Omicron variant omicron variant. Protein Receptor binding domain reduce respiratory SARS-CoV-2 SARS-CoV-2 nucleoprotein SARS-CoV-2 spike SARS-CoV-2 transmission SARS-CoV-2 variant severity significantly single dose suggested the antibody response the disease vaccination Vaccine virus infection wild-type [DOI] 10.1080/22221751.2022.2053365 PMC 바로가기 [Article Type] Article
Repertoires of SARS-CoV-2 epitopes targeted by antibodies vary according to severity of COVID-19코로나19 중증도에 따라 항체 표적 SARS-CoV-2 에피토프 레퍼토리 달라Article Published on 2022-12-012022-09-11 Journal: Virulence [Category] COVID19(2023년), SARS, 진단, 치료법, [키워드] antibodies antibody Antigen association Asymptomatic asymptomatic individual asymptomatic infection Betacoronavirus betacoronavirus Community convalescent correlated COVID-19 COVID-19 severity develop diagnosed diagnostics disease severity domains Epitopes Evidence evidence of finding FIVE five groups HKU1 Hospitalization IgG IgGs Immunity immunogenic immunogenic peptide individual Infection less MERS-CoV nucleocapsid protein Nucleocapsid proteins OC43 participant pathogenic pathogenic mechanisms peptide peptide array peptides pilot study predicted Protein RBDs reaction Receptor binding domain Region repertoire SARS-CoV RBD SARS-CoV RBDs SARS-CoV-2 SARS-CoV-2 epitope SARS-CoV-2 epitopes seroconverted Seroprevalence seroprevalence. severity severity of COVID-19 symptomatic symptomatic COVID-19 symptomatic infection therapeutic therapeutic antibodies Vaccines Viral with COVID-19 without symptoms [DOI] 10.1080/21505594.2022.2073025 PMC 바로가기 [Article Type] Article
Neutralizing antibodies to SARS-CoV-2 variants of concern including Delta and Omicron in subjects receiving mRNA-1273, BNT162b2, and Ad26.COV2.S vaccinesArticle Published on 2022-12-012022-11-15 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] Ad26.COV2.S Ad26.COV2.S vaccine antibody B.1.1.529 B.1.1.7 B.1.351 B.1.617.2 Beta BNT162b2 BNT162b2 vaccine booster center contributed Control COVID-19 Delta dose Effectiveness elicited faster FIVE Gamma immunization moderate mRNA-1273 mRNA-based vaccine Mutation Neutralizing Neutralizing antibodies neutralizing antibody omicron P.1 postvaccination prevention Protein pseudovirus receiving recipient recommendation robust SARS-CoV-2 SARS-CoV-2 vaccine SARS-CoV-2 variant subject Support vaccination Vaccine vaccine efficacy variants of concern variants of concern (VOCs). VoC VOCs wild type [DOI] 10.1002/jmv.28032 PMC 바로가기
Validation of SARS-CoV-2 pooled testing for surveillance using the Panther Fusion® system: Impact of pool size, automation, and assay chemistryArticle Published on 2022-11-072022-11-15 Journal: PLoS ONE [Category] SARS, 진단, 치료기술, [키워드] approach assays authorization automated conducted cut-off threshold cycle threshold decrease demonstrated diagnostic Emergency evaluated expected FDA FIVE generate Impact less limit of detection lowering nasopharyngeal sample nucleic acid amplification positive positive sample resources SARS-CoV-2 SARS-CoV-2 RNA sensitivity specificity specimen Surveillance surveillance testing System tested validation was used [DOI] 10.1371/journal.pone.0276729 PMC 바로가기
Identification of TCR repertoires in asymptomatic COVID-19 patients by single-cell T-cell receptor sequencingResearch article Published on 2022-11-012022-10-05 Journal: Blood cells, molecules & diseases [Category] COVID19(2023년), SARS, 변종, [키워드] analyzed Asymptomatic Asymptomatic COVID-19 asymptomatic infection cell-mediated immune response Combination COVID-19 COVID-19 patient dominant effective FIVE healthy control help identification identify Immunity Immunopathogenesis Immunotherapy J gene Patient PBMC performed SARS-CoV-2 SARS-COV-2 infection scTCR-seq Sequencing single-cell skewed study groups subjects symptomatic T cell response T-cell receptor TCR TCR repertoires TCR sequencing therapeutic strategy viral infection [DOI] 10.1016/j.bcmd.2022.102678 [Article Type] Research article
Towards Covid-19 TMPRSS2 enzyme inhibitors and antimicrobial agents: Synthesis, antimicrobial potency, molecular docking, and drug-likeness prediction of thiadiazole-triazole hybridsResearch article Published on 2022-11-012022-10-05 Journal: Journal of Molecular Structure [Category] 치료제, [키워드] 1 2 3 3-Triazoles 4-Thiadiazole analogue antimicrobial activity Bacillus subtilis binding affinity Candida albican candidate chalcone chloride Compound COVID-19 drug-likeness enzyme Escherichia coli exhibited FIVE Hydrazonoyl halides identify in silico in vitro inhibitor molecular docking pathogen Prevent proliferation Pseudomonas aeruginosa screened Staphylococcus aureus submitted synthesis synthesised therapeutic activity TMPRSS2 TMPRSS2 enzyme transmembrane serine protease Treatment Vanillin was tested [DOI] 10.1016/j.molstruc.2022.133659 [Article Type] Research article
Evaluation of five immunoassays and one lateral flow immunochromatography for anti-SARS-CoV-2 antibodies detectionArticle Published on 2022-11-012022-11-15 Journal: Enfermedades infecciosas y microbiologia clinica ( [Category] SARS, 진단, 치료기술, [키워드] addition anti-SARS-CoV-2 anti-SARS-CoV-2 antibodies anti-SARS-CoV-2 antibody approach caused CLIA CLIA assays Clinical practice complementary coronavirus SARS-CoV-2 COVID-19 COVID-19 patient criteria diagnostic ELISA English evaluated FIVE greater healthcare worker healthy IgG IgM IgM antibody immunoassay immunochromatographic test immunochromatography Inmunocromatografía involved lateral flow Pandemia pandemic para performed Rapid test ROC ROC curves RT-PCR SARS-CoV-2 SARS-CoV-2 coronavirus sensitivity Serología. serological serology serum sample Sin Spanish specificity Support Vaccine [DOI] 10.1016/j.eimce.2020.12.007 PMC 바로가기